The human genetic epidemiology of COVID-19
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
Host genetic factors determining COVID-19 susceptibility and severity
TP Velavan, SR Pallerla, J Rüter, Y Augustin… - …, 2021 - thelancet.com
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2
(SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections …
(SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections …
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …
Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants
Abstract The UK Biobank Pharma Proteomics Project (UKB-PPP) is a collaboration between
the UK Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma …
the UK Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma …
Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study
Background: Lipid metabolism plays an important role in viral infections. We aimed to
assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors, and …
assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors, and …
Genome-wide Mendelian randomization identifies actionable novel drug targets for psychiatric disorders
Psychiatric disorders impose tremendous economic burden on society and are leading
causes of disability worldwide. However, only limited drugs are available for psychiatric …
causes of disability worldwide. However, only limited drugs are available for psychiatric …
Causal inference with genetic data: Past, present, and future
JB Pingault, R Richmond… - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
The set of methods discussed in this collection has emerged from the convergence of two
scientific fields—genetics and causal inference. In this introduction, we discuss relevant …
scientific fields—genetics and causal inference. In this introduction, we discuss relevant …
Mendelian randomization as a tool for cardiovascular research: a review
Importance Mendelian randomization (MR) is a statistical approach that has become
increasingly popular in the field of cardiovascular disease research. It offers a way to infer …
increasingly popular in the field of cardiovascular disease research. It offers a way to infer …
NF-κB signaling and inflammation—Drug repurposing to treat inflammatory disorders?
A Roberti, LE Chaffey, DR Greaves - Biology, 2022 - mdpi.com
Simple Summary Since its first description 35 years ago, the transcription factor NF-κB
(nuclear factor κ-light-chain-enhancer of activated B cells) has been shown to be a key …
(nuclear factor κ-light-chain-enhancer of activated B cells) has been shown to be a key …
Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies
Background To summarize modifiable factors for coronavirus disease 2019 (COVID-19)
suggested by Mendelian randomization studies. Methods In this systematic review, we …
suggested by Mendelian randomization studies. Methods In this systematic review, we …