The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous
chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and …

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …

Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic
cardiovascular dysfunction also underscores the development of diabetic retinopathy …

In contrast to early lung development, a process exemplified by the branching of the
developing airways, the later development of the immature lung remains very poorly …

Hypoxic pulmonary hypertension (PH) is a progressive disease characterized by hyper-
proliferation of pulmonary vascular cells including pulmonary artery smooth muscle cells …

Autophagy is a highly conserved mechanism of lysosome-mediated protein and organelle
degradation that plays a crucial role in maintaining cellular homeostasis. In the last few …

Cardiovascular diseases are one of the leading causes of death. Increasing evidence has
shown that pharmacological or genetic targeting of mitochondria can ameliorate each stage …

Although nanoparticles have a great potential for biomedical applications, there is still a lack
of a correlative safety evaluation on the cardiovascular system. This study is aimed to clarify …

Autophagy, a cellular pathway for the degradation of damaged organelles and proteins, has
gained increasing importance in human pulmonary diseases, both as a modulator of …