Neuroendocrine and neuroimmune mechanisms underlying comorbidity of pain and obesity

DH Zhang, YH Fan, YQ Zhang, H Cao - Life Sciences, 2023 - Elsevier
Pain and obesity, as well as their associated impairments, are major health concerns.
Understanding the relationship between the two is the focus of a growing body of research …

[HTML][HTML] Spinal cord microglia drive sex differences in ethanol-mediated PGE2-induced allodynia

SN Alexander, OA Reed, MD Burton - Brain, Behavior, and Immunity, 2024 - Elsevier
The mechanisms of how long-term alcohol use can lead to persistent pain pathology are
unclear. Understanding how earlier events of short-term alcohol use can lower the threshold …

The influence of sex on neuroimmune communication, pain, and physiology

SN Alexander, AR Green, EK Debner… - Biology of sex …, 2024 - Springer
Abstract With the National Institutes of Health's mandate to consider sex as a biological
variable (SABV), there has been a significant increase of studies utilizing both sexes …

Ketolysis is required for the proper development and function of the somatosensory nervous system

J Enders, J Jack, S Thomas, P Lynch, S Lasnier… - Experimental …, 2023 - Elsevier
Ketogenic diets are emerging as protective interventions in preclinical and clinical models of
somatosensory nervous system disorders. Additionally, dysregulation of succinyl-CoA 3 …

Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program

KN Gilley, JI Fenton, SM Zick, K Li, L Wang… - Frontiers in …, 2024 - frontiersin.org
Introduction Despite progress in systemic lupus erythematosus (SLE) treatment, challenges
persist in medication adherence due to side effects and costs. Precision nutrition, particularly …

Sex-specific differences in alcohol-induced pain sensitization

SN Alexander, HS Jeong, TA Szabo-Pardi… - Neuropharmacology, 2023 - Elsevier
Pain sensitization is a phenomenon that occurs to protect tissues from damage and recent
studies have shown how a variety of non-noxious stimuli included in our everyday lives can …

[HTML][HTML] Loss of ATP-sensitive channel expression and function decreases opioid sensitivity in a mouse model of type 2 diabetes

C Fisher, K Johnson, M Moore, A Sadrati, JL Janecek… - bioRxiv, 2023 - ncbi.nlm.nih.gov
During diabetes, β-cell dysfunction due to loss of potassium channels sensitive to ATP,
known as K ATP channels occurs progressively over time contributing to hyperglycemia. K …

To identify biomarkers associated with the transfer of diabetes combined with cancer in human genes using bioinformatics analysis

Y Li, S Gu, X Li, Q Huang - Medicine, 2023 - journals.lww.com
Currently, the incidence of diabetes mellitus is increasing rapidly, particularly in China, and
its pathogenesis is still unclear. The goal of this study was to find meaningful biomarkers of …

Reducing dietary branched-chain amino acids intake alleviates high-fat diet-induced pain sensitization and postoperative pain in male mice

N Lian, F Li, K Luo, Y Kang, Y Yin, S Lui, T Li… - The Journal of …, 2024 - Elsevier
Background Poor dietary intake is associated with peripheral pain sensitization and
postoperative pain. Given the limited research on diet and pain, it is essential to examine the …

12/15-Lipoxygenases mediate neuropathic-like pain hypersensitivity in female mice

B Brown, I Chen, C Miliano, LB Murdaugh, Y Dong… - bioRxiv, 2024 - biorxiv.org
It is estimated that chronic neuropathic pain conditions exhibit up to 10% prevalence in the
general population, with increased incidence in females. However, nonsteroidal …