Atopic dermatitis endotypes and implications for targeted therapeutics
T Czarnowicki, H He, JG Krueger… - Journal of Allergy and …, 2019 - Elsevier
Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …
African genetic diversity and adaptation inform a precision medicine agenda
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …
humans more than 300,000 years ago, has resulted in high genetic diversity and …
[HTML][HTML] The genomics of human local adaptation
Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …
pressures, leading to multiple genetic adaptations to local environmental conditions. These …
[HTML][HTML] Human immunology through the lens of evolutionary genetics
L Quintana-Murci - Cell, 2019 - cell.com
Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …
Detecting such selection signatures in ancient and modern human genomes can thus help …
[HTML][HTML] Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde
Humans have undergone large migrations over the past hundreds to thousands of years,
exposing ourselves to new environments and selective pressures. Yet, evidence of ongoing …
exposing ourselves to new environments and selective pressures. Yet, evidence of ongoing …
[HTML][HTML] Human genetic admixture
KL Korunes, A Goldberg - PLoS genetics, 2021 - journals.plos.org
Throughout human history, large-scale migrations have facilitated the formation of
populations with ancestry from multiple previously separated populations. This process …
populations with ancestry from multiple previously separated populations. This process …
[HTML][HTML] Signatures of selection in admixed dairy cattle in Tanzania
Multiple studies have investigated selection signatures in domestic cattle and other species.
However, there is a dearth of information about the response to selection in genomes of …
However, there is a dearth of information about the response to selection in genomes of …
New insights into human immunity from ancient genomics
Population genetic studies have clearly indicated that immunity and host defense are among
the functions most frequently subject to natural selection, and increased our understanding …
the functions most frequently subject to natural selection, and increased our understanding …
Disentangling signatures of selection before and after European colonization in Latin Americans
J Mendoza-Revilla, JC Chacón-Duque… - Molecular biology …, 2022 - academic.oup.com
Throughout human evolutionary history, large-scale migrations have led to intermixing (ie,
admixture) between previously separated human groups. Although classical and recent …
admixture) between previously separated human groups. Although classical and recent …
[HTML][HTML] The genomic signatures of natural selection in admixed human populations
S Cuadros-Espinoza, G Laval, L Quintana-Murci… - The American Journal of …, 2022 - cell.com
Admixture has been a pervasive phenomenon in human history, extensively shaping the
patterns of population genetic diversity. There is increasing evidence to suggest that …
patterns of population genetic diversity. There is increasing evidence to suggest that …