Atopic dermatitis endotypes and implications for targeted therapeutics

T Czarnowicki, H He, JG Krueger… - Journal of Allergy and …, 2019 - Elsevier
Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …

African genetic diversity and adaptation inform a precision medicine agenda

L Pereira, L Mutesa, P Tindana, M Ramsay - Nature Reviews Genetics, 2021 - nature.com
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

[HTML][HTML] The genomics of human local adaptation

JS Rees, S Castellano, AM Andrés - Trends in Genetics, 2020 - cell.com
Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

[HTML][HTML] Human immunology through the lens of evolutionary genetics

L Quintana-Murci - Cell, 2019 - cell.com
Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

[HTML][HTML] Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde

I Hamid, KL Korunes, S Beleza, A Goldberg - Elife, 2021 - elifesciences.org
Humans have undergone large migrations over the past hundreds to thousands of years,
exposing ourselves to new environments and selective pressures. Yet, evidence of ongoing …

[HTML][HTML] Human genetic admixture

KL Korunes, A Goldberg - PLoS genetics, 2021 - journals.plos.org
Throughout human history, large-scale migrations have facilitated the formation of
populations with ancestry from multiple previously separated populations. This process …

[HTML][HTML] Signatures of selection in admixed dairy cattle in Tanzania

EK Cheruiyot, RC Bett, JO Amimo, Y Zhang… - Frontiers in …, 2018 - frontiersin.org
Multiple studies have investigated selection signatures in domestic cattle and other species.
However, there is a dearth of information about the response to selection in genomes of …

New insights into human immunity from ancient genomics

G Kerner, E Patin, L Quintana-Murci - Current Opinion in Immunology, 2021 - Elsevier
Population genetic studies have clearly indicated that immunity and host defense are among
the functions most frequently subject to natural selection, and increased our understanding …

Disentangling signatures of selection before and after European colonization in Latin Americans

J Mendoza-Revilla, JC Chacón-Duque… - Molecular biology …, 2022 - academic.oup.com
Throughout human evolutionary history, large-scale migrations have led to intermixing (ie,
admixture) between previously separated human groups. Although classical and recent …

[HTML][HTML] The genomic signatures of natural selection in admixed human populations

S Cuadros-Espinoza, G Laval, L Quintana-Murci… - The American Journal of …, 2022 - cell.com
Admixture has been a pervasive phenomenon in human history, extensively shaping the
patterns of population genetic diversity. There is increasing evidence to suggest that …