Abstract Cancer-associated fibroblasts (CAFs), as a central component of the tumor
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …

No longer viewed as a metabolic waste product and cause of muscle fatigue, a
contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in …

Metabolic reprogramming is one of fourteen hallmarks of tumor cells, among which aerobic
glycolysis, often known as the “Warburg effect,” is essential to the fast proliferation and …

Glycolysis is highly enhanced in pancreatic ductal adenocarcinoma (PDAC) cells; thus,
glucose restrictions are imposed on nontumor cells in the PDAC tumor microenvironment …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

In recent years, research focused on the multifaceted landscape and functions of cancer-
associated fibroblasts (CAFs) aimed to reveal their heterogeneity and identify commonalities …

Simple Summary Advanced prostate cancer remains a clinical challenge, requiring novel
therapeutic treatments and biomarkers for patient-risk stratification. From a metabolic …

Cellular metabolites are ancient molecules with pleiotropic implications in health and
disease. Beyond their cognate roles, they have signaling functions as the ligands for specific …

Tissue-resident fibroblasts are mesenchymal cells which control the structural integrity of the
extracellular matrix (ECM). Fibroblasts possess a remarkable plasticity to allow them to …

In recent years, the significant impact of lactate in the tumor microenvironment has been
greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is …