Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic
actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of …

Lamina-associated polypeptide 1 (LAP1) is a nuclear envelope (NE) protein whose function
remains poorly characterized. In a recent LAP1 protein interactome study, a putative …

Introduction: Astrocytes are the glial cells responsible for brain homeostasis, but if injured,
they could damage neural cells even deadly. Genetic damage, DNA damage response …

Development of vehicles for the subcellular targeted delivery of biologically active agents is
very promising for the purposes of translational medicine. This review summarizes the …

Astronauts on missions beyond low-Earth orbit are exposed to a hostile environment in
which they are continually bombarded with unique high-energy species of radiation, while in …

Astrocytes maintain CNS homeostasis but also critically contribute to neurological and
psychiatric disorders. Such functional diversity implies an extensive signaling repertoire …

In response to DNA double-strand breaks (DSB), histone H2AX is phosphorylated around
the lesion by a feed forward signal amplification loop, originating γH2AX foci detectable by …

DNA damage response (DDR) constitutes a protein pathway to handle eukaryotic DNA
lesions in the context of chromatin. DDR engages the recruitment of signaling, transducer …

The key protein in the canonical Wnt pathway is β-catenin, which is phosphorylated both in
absence and presence of Wnt signals by different kinases. Upon activation in the cytoplasm …

2 Background: Active Contour Models and Multiple-Object Segmentation 11 2.1 Membrane
Detection in Fluorescence Microscopy............... 12 2.1. 1 Fluorescence …