Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review

M Mohajeri, A Sahebkar - Critical reviews in oncology/hematology, 2018 - Elsevier
Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …

Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity

AI Abushouk, A Ismail, AMA Salem, AM Afifi… - Biomedicine & …, 2017 - Elsevier
Doxorubicin (DOX) is an anthracycline antibiotic, which is effectively used in the treatment of
different malignancies, such as leukemias and lymphomas. Its most serious side effect is …

[HTML][HTML] MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2

L Zhao, Y Qi, L Xu, X Tao, X Han, L Yin, J Peng - Redox biology, 2018 - Elsevier
Clinical application of doxorubicin (DOX), an anthracycline antibiotic with potent anti-tumor
effects, is limited because of its cardiotoxicity. However, its pathogenesis is still not entirely …

[HTML][HTML] Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress

L Zhao, X Tao, Y Qi, L Xu, L Yin, J Peng - Redox biology, 2018 - Elsevier
Clinical application of doxorubicin (DOX) is limited because of its cardiotoxicity. Thus,
exploration of effective lead compounds against DOX-induced cardiotoxicity is necessary …

Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis

EM Mantawy, WM El-Bakly, A Esmat, AM Badr… - European journal of …, 2014 - Elsevier
Doxorubicin (DOX) is one of the most effective chemotherapeutic drugs; however, its
incidence of cardiotoxicity compromises its therapeutic index. Chrysin, a natural flavone …

Curcumin ameliorates doxorubicin‐induced cardiotoxicity by abrogation of inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats

F Benzer, FM Kandemir, M Ozkaraca… - … of biochemical and …, 2018 - Wiley Online Library
Doxorubicin (DXR) is a highly effective drug for chemotherapy. However, cardiotoxicity
reduces its clinical utility in humans. The present study aimed to assess the ameliorative …

Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis

RA Shaker, SH Abboud, HC Assad, N Hadi - BMC Pharmacology and …, 2018 - Springer
Background Doxorubicin (DOX) is commonly used in the treatment of many types of cancers
but its cardiotoxicity is limiting its clinical use. Beyond its anticoagulant action, enoxaparin …

Green synthesis of Ag nanoparticles/clinoptilolite using Vaccinium macrocarpon fruit extract and its excellent catalytic activity for reduction of organic dyes

B Khodadadi, M Bordbar, A Yeganeh-Faal… - Journal of Alloys and …, 2017 - Elsevier
The Vaccinium macrocarpon fruit extract was used to green synthesis of silver nanoparticles
(Ag NPs) supported on the surface of clinoptilolite through the reduction of Ag+ ions to Ag …

Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

C Zhang, Y Feng, S Qu, X Wei, H Zhu… - Cardiovascular …, 2011 - academic.oup.com
Aims Doxorubicin (DOX) is an anthracycline drug with a wide spectrum of clinical
antineoplastic activity, but increased apoptosis has been implicated in its cardiotoxicity …

Modulation of Nrf2 by quercetin in doxorubicin-treated rats

A Sharma, M Parikh, H Shah, T Gandhi - Heliyon, 2020 - cell.com
Doxorubicin (DOXO), a potent and widely used chemotherapeutic agent, causes irreversible
heart failure by increasing oxidative stress, which limits its clinical utility. Nuclear factor …