The probabilistic model of Alzheimer disease: the amyloid hypothesis revised
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
[HTML][HTML] The complex genetic architecture of Alzheimer's disease: novel insights and future directions
SJ Andrews, AE Renton, B Fulton-Howard… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …
disorder and the most common form of dementia. AD is highly heritable, with heritability …
[HTML][HTML] Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
A major unanswered question in the dementia field is whether cognitively unimpaired
individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is …
individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is …
[PDF][PDF] Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …
Merged magnetic resonance and light sheet microscopy of the whole mouse brain
We have developed workflows to align 3D magnetic resonance histology (MRH) of the
mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen …
mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen …
Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease
Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer's
disease, but the functional brain mechanisms that support cognitive resilience remain …
disease, but the functional brain mechanisms that support cognitive resilience remain …
[HTML][HTML] Glycolytic metabolism, brain resilience, and Alzheimer's disease
X Zhang, N Alshakhshir, L Zhao - Frontiers in Neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is the most common form of age-related dementia. Despite
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …
Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease
DP Veitch, MW Weiner, PS Aisen… - Alzheimer's & …, 2022 - Wiley Online Library
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …
[HTML][HTML] Protective genes and pathways in Alzheimer's disease: moving towards precision interventions
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
[HTML][HTML] Translational approaches to understanding resilience to Alzheimer's disease
Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …