[HTML][HTML] The Intriguing Evolutionary Journey of Enteroinvasive E. coli (EIEC) toward Pathogenicity

M Pasqua, V Michelacci, ML Di Martino… - Frontiers in …, 2017 - frontiersin.org
Among the intestinal pathogenic Escherichia coli, enteroinvasive E. coli (EIEC) are a group
of intracellular pathogens able to enter epithelial cells of colon, multiplicate within them, and …

[HTML][HTML] Host-bacterial pathogen communication: the wily role of the multidrug efflux pumps of the MFS family

M Pasqua, MC Bonaccorsi di Patti, G Fanelli… - Frontiers in Molecular …, 2021 - frontiersin.org
Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to
the surroundings depends on their ability to sense environmental variations and to respond …

[HTML][HTML] AcrAB efflux pump impacts on the survival of adherent-invasive Escherichia coli strain LF82 inside macrophages

G Fanelli, M Pasqua, G Prosseda, M Grossi… - Scientific Reports, 2023 - nature.com
Abstract The tripartite complex AcrAB-TolC is the major RND pump in Escherichia coli and
other Enterobacteriaceae. It consists of the AcrB transporter, which is embedded in the inner …

[HTML][HTML] Roles of two-component signal transduction systems in Shigella virulence

M Pasqua, M Coluccia, Y Eguchi, T Okajima, M Grossi… - Biomolecules, 2022 - mdpi.com
Two-component signal transduction systems (TCSs) are widespread types of protein
machinery, typically consisting of a histidine kinase membrane sensor and a cytoplasmic …

[HTML][HTML] The MFS efflux pump EmrKY contributes to the survival of Shigella within macrophages

M Pasqua, M Grossi, S Scinicariello, L Aussel… - Scientific reports, 2019 - nature.com
Efflux pumps are membrane protein complexes conserved in all living organisms. Beyond
being involved in antibiotic extrusion in several bacteria, efflux pumps are emerging as …

Fatty Acids Abolish Shigella Virulence by Inhibiting Its Master Regulator, VirF

R Trirocco, M Pasqua, A Tramonti, M Grossi… - Microbiology …, 2023 - Am Soc Microbiol
The pathogenicity of Shigella, the intracellular pathogen responsible for human bacillary
dysentery, depends on a coordinated and tightly regulated expression of its virulence …

[HTML][HTML] Diffusible signal factors (DSFs) bind and repress VirF, the leading virulence activator of Shigella flexneri

R Trirocco, M Pasqua, A Tramonti, B Colonna… - Scientific Reports, 2023 - nature.com
Shigella, the aetiological agent of human bacillary dysentery, controls the expression of its
virulence determinants through an environmentally stimulated cascade of transcriptional …

[HTML][HTML] Role of the MDR Efflux Pump AcrAB in Epithelial Cell Invasion by Shigella flexneri

M Coluccia, A Béranger, R Trirocco, G Fanelli, F Zanzi… - Biomolecules, 2023 - mdpi.com
The tripartite complex AcrAB-TolC is the major RND pump in Escherichia coli and other
Enterobacteriaceae, including Shigella, the etiological agent of bacillary dysentery. In …

[HTML][HTML] Expression Profile of Multidrug Resistance Efflux Pumps During Intracellular Life of Adherent-Invasive Escherichia coli Strain LF82

G Fanelli, M Pasqua, B Colonna, G Prosseda… - Frontiers in …, 2020 - frontiersin.org
Efflux pumps (EPs) are present in all living cells and represent a large and important group
of transmembrane proteins involved in transport processes. In bacteria, multidrug resistance …

[HTML][HTML] Modulation of OMV Production by the Lysis Module of the DLP12 Defective Prophage of Escherichia coli K12

M Pasqua, A Zennaro, R Trirocco, G Fanelli, G Micheli… - Microorganisms, 2021 - mdpi.com
Outer membrane vesicles (OMVs) are nanostructures mostly produced by blebbing of the
outer membrane in Gram negative bacteria. They contain biologically active proteins and …