DNA methylation profiling: an emerging paradigm for cancer diagnosis
A Papanicolau-Sengos, K Aldape - Annual Review of Pathology …, 2022 - annualreviews.org
Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities
T Ge, X Gu, R Jia, S Ge, P Chai… - Cancer …, 2022 - Wiley Online Library
Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …
Landscape of microsatellite instability across 39 cancer types
Purpose Microsatellite instability (MSI) is a pattern of hypermutation that occurs at genomic
microsatellites and is caused by defects in the mismatch repair system. Mismatch repair …
microsatellites and is caused by defects in the mismatch repair system. Mismatch repair …
ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade
Abstract ARID1A (the AT-rich interaction domain 1A, also known as BAF250a) is one of the
most commonly mutated genes in cancer,. The majority of ARID1A mutations are inactivating …
most commonly mutated genes in cancer,. The majority of ARID1A mutations are inactivating …
Microsatellite instability as a biomarker for PD-1 blockade
Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the
New England Journal of Medicine, report significant responses of cancers with microsatellite …
New England Journal of Medicine, report significant responses of cancers with microsatellite …
Epigenetic alterations in colorectal cancer: emerging biomarkers
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …
fundamental processes driving the initiation and progression of CRC is the accumulation of …
Milestones of Lynch syndrome: 1895–2015
HT Lynch, CL Snyder, TG Shaw, CD Heinen… - Nature Reviews …, 2015 - nature.com
Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
Defining driver DNA methylation changes in human cancer
GP Pfeifer - International journal of molecular sciences, 2018 - mdpi.com
Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …
methylation. These changes include a globally hypomethylated tumor cell genome and the …
[HTML][HTML] Epigenetic alterations in cancer
Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …
Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies
S Venderbosch, ID Nagtegaal, TS Maughan… - Clinical Cancer …, 2014 - AACR
Purpose: To determine the prevalence and prognostic value of mismatch repair (MMR)
status and its relation to BRAF mutation (BRAF MT) status in metastatic colorectal cancer …
status and its relation to BRAF mutation (BRAF MT) status in metastatic colorectal cancer …