Neurogenesis, the process of generating neurons from neural stem cells, occurs during both
embryonic and adult stages, with each stage possessing distinct characteristics. Dysfunction …

How cells regulate protein levels is a central question of biology. Over the past decades,
molecular biology research has provided profound insights into the mechanisms and the …

Variation in gene expression across lineages is thought to explain much of the observed
phenotypic variation and adaptation. The protein is closer to the target of natural selection …

The heterogeneity of aging has been investigated at cellular and organic levels in the
mouse model and human, but the exploration of aging heterogeneity at whole‐organism …

To support PTM proteomic analysis and annotation in different species, we developed
PTMoreR, a user-friendly tool that considers the surrounding amino acid sequences of PTM …

The prevalence of type 2 diabetes (T2DM) is increasing globally, creating essential
demands for T2DM animal models for the study of disease pathogenesis, prevention, and …

Gene expression change is a dominant mode of evolution. Mutations, however, can affect
gene expression in multiple cell types. Therefore, gene expression evolution in one cell type …

The regulatory mechanisms that shape mRNA and protein abundances are intensely
studied. Much less is known about the evolutionary processes that shape the relationship …

Protein function annotation has been one of the longstanding issues, which is key for
discovering drug targets and understanding physiological or pathological process. A variety …

Arthritis, a diverse group of inflammatory joint disorders, poses great challenges in early
diagnosis and targeted treatment. Timely intervention is imperative, yet conventional …