Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Oxidative stress has been defined as an imbalance between oxidants and antioxidants and
more recently as a disruption of redox signaling and control. It is generally accepted that …

Briefly, measurement of flow-mediated vasodilation (FMD) of the brachial artery has been
used for the assessment of endothelial function in humans. 14, 15 This technique measures …

Pyroptosis is a form of programmed necrosis, and is morphologically and mechanistically
unique form of programmed cell death compared to others, such as apoptosis and …

Chronic inflammation is a central pathogenic mechanism of atherosclerosis induction and
progression. Vascular inflammation is associated with accelerated onset of late …

Chronic kidney disease (CKD) is associated with accelerated atherosclerosis progression
and high incidence of cardiovascular events, hinting that atherosclerotic plaques in CKD …

Thymoquinone (TQ) is a bioactive component of black seed (Nigella sativa) volatile oil and
has been shown to have anti-oxidative, anti-inflammatory, and anti-cancer properties. In the …

A cluster of miR‐221/222 is a key player in vascular biology through exhibiting its effects on
vascular smooth muscle cells (VSMCs) and endothelial cells (ECs). These miRNAs …

Events responsible for cardiovascular mortality and morbidity are predominantly caused by
rupture of “vulnerable” atherosclerotic lesions. Vascular smooth muscle cells (VSMCs) play …