Stroke instigates a dynamic process of repair and remodelling of remaining neural circuits,
and this process is shaped by behavioural experiences. The onset of motor disability …

Purpose This paper reviews 10 principles of experience-dependent neural plasticity and
considerations in applying them to the damaged brain. Method Neuroscience research …

Rehabilitation after hemiplegic stroke has typically relied on the training of patients in
compensatory strategies. The translation of neuroscientific research into care has led to new …

The motor cortex and spinal cord possess the remarkable ability to alter structure and
function in response to differential motor training. Here we review the evidence that the …

Many studies in human and animal models have shown that neural plasticity compensates
for the loss of motor function after stroke. However, neural plasticity concerning …

Therapies for motor recovery after stroke or traumatic brain injury are still not satisfactory. To
date the best approach seems to be the intensive physical therapy. However the results are …

Decades of basic science have clearly demonstrated the capacity of the central nervous
system (CNS) to structurally and functionally adapt in response to experience. The field of …

Voluntary exercise, treadmill activity, skills training, and forced limb use have been utilized in
animal studies to promote brain plasticity and functional change. Motor enrichment may …

The past decade of neuroscience research has provided considerable evidence that the
adult brain can undergo substantial reorganization following injury. For example, following …

Stroke instigates regenerative responses that reorganize connectivity patterns among
surviving neurons. The new connectivity patterns can be suboptimal for behavioral function …