Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models
Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …
challenges facing cardiovascular medicine today. Despite being the most common form of …
Cardiac metabolism in HFpEF: from fuel to signalling
Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …
energy substrates. Among the different types of HF, HF with preserved ejection fraction …
Impaired T cell IRE1α/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) is a widespread syndrome with limited
therapeutic options and poorly understood immune pathophysiology. Using a 2-hit …
therapeutic options and poorly understood immune pathophysiology. Using a 2-hit …
Inflammation in obesity-related HFpEF: the STEP-HFpEF program
Background Inflammation is thought to be an important mechanism for the development and
progression of obesity-related heart failure with preserved ejection fraction (HFpEF). In the …
progression of obesity-related heart failure with preserved ejection fraction (HFpEF). In the …
Fibroblasts and immune cells: At the crossroad of organ inflammation and fibrosis
S Smolgovsky, B Theall, N Wagner… - American Journal of …, 2024 - journals.physiology.org
The immune and fibrotic responses have evolved to work in tandem to respond to pathogen
clearance and promote tissue repair. However, excessive immune and fibrotic responses …
clearance and promote tissue repair. However, excessive immune and fibrotic responses …
Contributions of inflammation to cardiometabolic heart failure with preserved ejection fraction
EB Thorp, M Filipp - Annual Review of Pathology: Mechanisms …, 2024 - annualreviews.org
The most common form of heart failure is heart failure with preserved ejection fraction
(HFpEF). While heterogeneous in origin, the most common form of HFpEF is the …
(HFpEF). While heterogeneous in origin, the most common form of HFpEF is the …
Single-cell RNA sequencing reveals metabolic stress-dependent activation of cardiac macrophages in a model of dyslipidemia-induced diastolic dysfunction
BACKGROUND: Metabolic distress is often associated with heart failure with preserved
ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced …
ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced …
The aging heart in focus: The advanced understanding of heart failure with preserved ejection fraction
Z Zhang, Y Wang, X Chen, C Wu, J Zhou, Y Chen… - Ageing Research …, 2024 - Elsevier
Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of heart failure (HF)
cases, making it the most common type of HF, and its prevalence continues to increase in …
cases, making it the most common type of HF, and its prevalence continues to increase in …
Myocardial inflammation in heart failure with reduced and preserved ejection fraction
P Alcaide, M Kallikourdis, R Emig… - Circulation Research, 2024 - Am Heart Assoc
Heart failure (HF) is characterized by a progressive decline in cardiac function and
represents one of the largest health burdens worldwide. Clinically, 2 major types of HF are …
represents one of the largest health burdens worldwide. Clinically, 2 major types of HF are …
Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF
A Yoshii, TS McMillen, Y Wang, B Zhou… - Circulation …, 2024 - ahajournals.org
BACKGROUND: Metabolic remodeling and mitochondrial dysfunction are hallmarks of heart
failure with reduced ejection fraction. However, their role in the pathogenesis of HF with …
failure with reduced ejection fraction. However, their role in the pathogenesis of HF with …