Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models

J Roh, JA Hill, A Singh, M Valero-Muñoz… - Circulation …, 2022 - Am Heart Assoc
Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …

Cardiac metabolism in HFpEF: from fuel to signalling

F Capone, C Sotomayor-Flores, D Bode… - Cardiovascular …, 2022 - academic.oup.com
Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

Impaired T cell IRE1α/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction

S Smolgovsky, AL Bayer, K Kaur… - The Journal of …, 2023 - Am Soc Clin Investig
Heart failure with preserved ejection fraction (HFpEF) is a widespread syndrome with limited
therapeutic options and poorly understood immune pathophysiology. Using a 2-hit …

Inflammation in obesity-related HFpEF: the STEP-HFpEF program

S Verma, MC Petrie, BA Borlaug, J Butler… - Journal of the American …, 2024 - jacc.org
Background Inflammation is thought to be an important mechanism for the development and
progression of obesity-related heart failure with preserved ejection fraction (HFpEF). In the …

Fibroblasts and immune cells: At the crossroad of organ inflammation and fibrosis

S Smolgovsky, B Theall, N Wagner… - American Journal of …, 2024 - journals.physiology.org
The immune and fibrotic responses have evolved to work in tandem to respond to pathogen
clearance and promote tissue repair. However, excessive immune and fibrotic responses …

Contributions of inflammation to cardiometabolic heart failure with preserved ejection fraction

EB Thorp, M Filipp - Annual Review of Pathology: Mechanisms …, 2024 - annualreviews.org
The most common form of heart failure is heart failure with preserved ejection fraction
(HFpEF). While heterogeneous in origin, the most common form of HFpEF is the …

Single-cell RNA sequencing reveals metabolic stress-dependent activation of cardiac macrophages in a model of dyslipidemia-induced diastolic dysfunction

C Panico, A Felicetta, P Kunderfranco, M Cremonesi… - Circulation, 2024 - ahajournals.org
BACKGROUND: Metabolic distress is often associated with heart failure with preserved
ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced …

The aging heart in focus: The advanced understanding of heart failure with preserved ejection fraction

Z Zhang, Y Wang, X Chen, C Wu, J Zhou, Y Chen… - Ageing Research …, 2024 - Elsevier
Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of heart failure (HF)
cases, making it the most common type of HF, and its prevalence continues to increase in …

Myocardial inflammation in heart failure with reduced and preserved ejection fraction

P Alcaide, M Kallikourdis, R Emig… - Circulation Research, 2024 - Am Heart Assoc
Heart failure (HF) is characterized by a progressive decline in cardiac function and
represents one of the largest health burdens worldwide. Clinically, 2 major types of HF are …

Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF

A Yoshii, TS McMillen, Y Wang, B Zhou… - Circulation …, 2024 - ahajournals.org
BACKGROUND: Metabolic remodeling and mitochondrial dysfunction are hallmarks of heart
failure with reduced ejection fraction. However, their role in the pathogenesis of HF with …