This evidence-based clinical practice guideline is a revision of the 2004 acute otitis media
(AOM) guideline from the American Academy of Pediatrics (AAP) and American Academy of …

This paper attempts to summarize current knowledge about immune responses to vaccines
that correlate with protection. Although the immune system is redundant, almost all current …

Background Influenza vaccines are most effective when the antigens in the vaccine match
those of circulating strains. However, antigens contained in the vaccines do not always …

Correlates of protection (CoPs) are increasingly important in the development and licensure
of vaccines. Although the study of CoPs was initially directed at identifying a single immune …

Influenza A and B virus infections are a major cause of respiratory disease in humans and
are responsible for substantial morbidity and mortality worldwide. Vaccination against …

In March and early April 2009 a new swine-origin influenza virus (S-OIV), A (H1N1),
emerged in Mexico and the USA. The virus quickly spread worldwide through human-to …

The success of the first licensed mRNA-based vaccines against COVID-19 has created a
widespread interest on mRNA technology for vaccinology. As expected, the number of …

Background The consequences of influenza in children and adults are mainly absenteeism
from school and work. However, the risk of complications is greatest in children and people …

Background New influenza vaccines eliciting more effective protection are needed,
particularly for the elderly who paid a large and disproportional toll of hospitalization and …

Immunization is one of the great advances in public health. Figure 0.1 shows a camel with a
solar-powered refrigerator on his back carrying vaccines across a hot desert to the far …