Therapeutic progression of quinazolines as targeted chemotherapeutic agents
R Bansal, A Malhotra - European Journal of Medicinal Chemistry, 2021 - Elsevier
Presently cancer is a grave health issue with predominance beyond restrictions. It can affect
any organ of the body. Most of the available chemotherapeutic drugs are highly toxic, not …
any organ of the body. Most of the available chemotherapeutic drugs are highly toxic, not …
Quinazoline derivatives as potential therapeutic agents in urinary bladder cancer therapy
P Wdowiak, J Matysiak, P Kuszta, K Czarnek… - Frontiers in …, 2021 - frontiersin.org
Cancer diseases remain major health problems in the world despite significant
developments in diagnostic methods and medications. Many of the conventional therapies …
developments in diagnostic methods and medications. Many of the conventional therapies …
Discovery of novel quinoline–chalcone derivatives as potent antitumor agents with microtubule polymerization inhibitory activity
A series of novel quinoline–chalcone derivatives were designed, synthesized, and
evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most …
evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most …
Design, synthesis, and biological evaluation of heterocyclic-fused pyrimidine chemotypes guided by X-ray crystal structure with potential antitumor and anti-multidrug …
L Tan, C Wu, J Zhang, Q Yu, X Wang… - Journal of Medicinal …, 2023 - ACS Publications
Herein, a series of quinazoline and heterocyclic fused pyrimidine analogues were designed
and synthesized based on the X-ray co-crystal structure of lead compound 3a, showing …
and synthesized based on the X-ray co-crystal structure of lead compound 3a, showing …
Characterization of gamma-ray and neutron radiation absorption properties of synthesized quinoline derivatives and their genotoxic potential
In this study, six different types of quinoline derivatives were synthesized, which can be used
as an anti-radiation drug for active matter and its effects against radiation was determined …
as an anti-radiation drug for active matter and its effects against radiation was determined …
An update on the recent advances and discovery of novel tubulin colchicine binding inhibitors
H Weng, J Li, H Zhu, KF Carver Wong… - Future Medicinal …, 2023 - Taylor & Francis
Microtubules, formed by α-and β-tubulin heterodimer, are considered as a major target to
prevent the proliferation of tumor cells. Microtubule-targeted agents have become …
prevent the proliferation of tumor cells. Microtubule-targeted agents have become …
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site
A series of novel isocombretastatin A-4 (isoCA-4) analogs were designed and synthesized
by replacing 3, 4, 5-trimethoylphenyl and isovanillin of isoCA-4 with quinoline and indole …
by replacing 3, 4, 5-trimethoylphenyl and isovanillin of isoCA-4 with quinoline and indole …
Design and synthesis of newer 1, 3, 4-oxadiazole and 1, 2, 4-triazole based Topsentin analogues as anti-proliferative agent targeting tubulin
A set of two series of 1, 3, 4-oxadiazole (11a-n) and 1, 2, 4-Triazole (12a, c, e, g, h, jn) based
topsentin analogues were prepared by replacing imizadole moiety of topsentin through a …
topsentin analogues were prepared by replacing imizadole moiety of topsentin through a …
Discovery of a novel vascular disrupting agent inhibiting tubulin polymerization and HDACs with potent antitumor effects
H Zhu, Y Tan, C He, Y Liu, Y Duan, W Zhu… - Journal of medicinal …, 2022 - ACS Publications
Most vascular disrupting agents (VDAs) fail to prevent the regrowth of blood vessels at the
edge of tumors, causing tumor rebound and relapse. Herein, a series of novel …
edge of tumors, causing tumor rebound and relapse. Herein, a series of novel …
Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents
Further optimization of the trimethoxyphenyl scaffold of parent chalcone compound (2a) by
introducing a pyridine ring afforded a series of novel pyridine-chalcone derivatives as …
introducing a pyridine ring afforded a series of novel pyridine-chalcone derivatives as …