The Fanconi anaemia pathway repairs DNA interstrand crosslinks (ICLs) in the genome. Our
understanding of this complex pathway is still evolving, as new components continue to be …

Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

Oncogene activation creates DNA replication stress (RS) in cancer cells, which can
generate under-replicated DNA regions (UDRs) that persist until cells enter mitosis. UDRs …

Genome instability is a feature of cancer cells, transcription being an important source of
DNA damage. This is in large part associated with R-loops, which hamper replication …

Common fragile sites (CFSs) are genomic regions that are unstable under conditions of
replicative stress. Although the characteristics of CFSs that render them vulnerable to stress …

The extremely high cancer incidence associated with patients suffering from a rare human
genetic disease, Fanconi anemia (FA), demonstrates the importance of FA genes. Over the …

In 1927 Guido Fanconi described a hereditary condition presenting panmyelopathy
accompanied by short stature and hyperpigmentation, now better known as Fanconi anemia …

Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory
mechanisms for promoting DNA repair and the DNA damage response in mammalian cells …

An extremely high cancer incidence and the hypersensitivity to DNA crosslinking agents
associated with Fanconi Anemia (FA) have marked it to be a unique genetic model system to …

Radiotherapy is one of the standard therapeutic regimens for medulloblastoma (MB). Tumor
cells utilize DNA damage repair (DDR) mechanisms to survive and develop resistance …