Physiological effect of ghrelin on body systems

Y Akalu, MD Molla, G Dessie… - International journal of …, 2020 - Wiley Online Library
Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of
physiological effects. In this review, we found/confirmed that ghrelin has effect on all body …

Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle

JB Soares, AF Leite-Moreira - peptides, 2008 - Elsevier
The major active product of ghrelin gene is a 28-amino acid peptide acylated at the serine 3
position with an octanoyl group, called simply ghrelin. Ghrelin has a multiplicity of …

Physiological, pathological and potential therapeutic roles of ghrelin

AF Leite-Moreira, JB Soares - Drug discovery today, 2007 - Elsevier
Ghrelin, a hormone that is produced mainly by the stomach, was identified originally as the
endogenous ligand of the growth hormone secretagogue (GHS) receptor. Ghrelin might also …

Novel and conventional receptors for ghrelin, desacyl-ghrelin, and pharmacologically related compounds

B Callaghan, JB Furness - Pharmacological reviews, 2014 - ASPET
The only molecularly identified ghrelin receptor is the growth hormone secretagogue
receptor GHSR1a. Its natural ligand, ghrelin, is an acylated peptide whose unacylated …

Ghrelin and cardiovascular diseases

G Zhang, X Yin, Y Qi, L Pendyala… - Current cardiology …, 2010 - ingentaconnect.com
Ghrelin, a newly discovered bioactive peptide, is a natural endogenous ligand of the growth
hormone (GH) secretagogue receptor and initially identified as a strong stimulant for the …

Ghrelin and the cardiovascular system

BM Lilleness, WH Frishman - Cardiology in review, 2016 - journals.lww.com
Ghrelin is a small peptide released primarily from the stomach. It is a potent stimulator of
growth hormone secretion from the pituitary gland and is well known for its regulation of …

Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure

A Beiras-Fernandez, S Kreth, F Weis, C Ledderose… - Peptides, 2010 - Elsevier
Ghrelin is a peptide hormone mainly produced by the stomach, which strongly stimulates the
release of growth hormone (GH) via the GH secretagogue receptor 1a (GHSR-1a) located in …

Cardiovascular actions of the ghrelin gene-derived peptides and growth hormone-releasing hormone

R Granata, J Isgaard, G Alloatti… - … Biology and Medicine, 2011 - journals.sagepub.com
In 1976, small peptide growth hormone secretagogues (GHSs) were discovered and found
to promote growth hormone (GH) release from the pituitary. The GHS receptor (GHS-R) was …

Integrating GHS into the ghrelin system

JD Veldhuis, CY Bowers - International journal of peptides, 2010 - Wiley Online Library
Oligopeptide derivatives of metenkephalin were found to stimulate growth‐hormone (GH)
release directly by pituitary somatotrope cells in vitro in 1977. Members of this class of …

Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats

DO Schwenke, T Tokudome, M Shirai, H Hosoda… - …, 2008 - academic.oup.com
Chronic exposure to hypoxia, a common adverse consequence of most pulmonary
disorders, can lead to a sustained increase in pulmonary arterial pressure (PAP), right …