Mucosal vaccines offer the potential to trigger robust protective immune responses at the
predominant sites of pathogen infection. In principle, the induction of adaptive immunity at …

The importance of vaccination has been proven particularly significant the last three years,
as it is revealed to be the most efficient weapon for the prevention of several infections …

Although inoculation of COVID-19 vaccines has rolled out globally, there is still a critical
need for safe and effective vaccines to ensure fair and equitable supply for all countries …

Background Bordetella pertussis epidemics persist as transmission remains unabated
despite high acellular pertussis vaccination rates. BPZE1, a live attenuated intranasal …

Viruses, bacteria, fungi, and several other pathogenic microorganisms usually infect the host
via the surface cells of respiratory mucosa. Nasal vaccination could provide a strong …

Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh)
cell interactions. Whether these interactions are impaired and associated with COVID-19 …

BACKGROUND To date, only limited data are available on the mechanisms of protection
against colonization with Bordetella pertussis in humans. METHODS In this study, the …

Background Long-term protection and herd immunity induced by existing pertussis vaccines
are imperfect, and a need therefore exists to develop new pertussis vaccines. This study …

Bordetella pertussis and Bordetella bronchiseptica belong to the genus Bordetella, which
comprises 14 other species. B. pertussis is responsible for whooping cough in humans, a …

Effective antigen delivery and immune stimulation in nasal mucosa determine the success of
mucosal immunity. Here, an oil-in-ionic liquid (o/IL) nanoemulsion formulated with choline …