Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Rationale: The Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In
Cardiac Disease (CUPID 1) study was a phase 1/phase 2 first-in-human clinical gene …

Objectives: Impaired cardiac isoform of sarco (endo) plasmic reticulum Ca2+ ATPase
(SERCA2a) activity is a key abnormality in heart failure patients with reduced ejection …

Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a
reversible regulator of the Ca2+-ATPase (SERCA2a) activity and cardiac contractility …

Ongoing efforts to generate a complete and accurate annotation of the genome have
revealed a significant blind spot for small proteins (< 100 amino acids) originating from short …

The SERCA-LVAD trial was a phase 2a trial assessing the safety and feasibility of delivering
an adeno-associated vector 1 carrying the cardiac isoform of the sarcoplasmic reticulum …

Iron-overload cardiomyopathy is a prevalent cause of heart failure on a world-wide basis
and is a major cause of mortality and morbidity in patients with secondary iron-overload and …

Ultrasound-targeted microbubble destruction (UTMD) has recently drawn considerable
attention in biomedicine applications due to its great potential to locally enhance gene …

BACKGROUND: Adeno-associated virus (AAV) has emerged as one of the best tools for
cardiac gene delivery due to its cardiotropism, long-term expression, and safety. However, a …