Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …

Diazirines are among the smallest photoreactive groups that form a reactive carbene upon
light irradiation. This feature has been widely utilized in photoaffinity labeling to study ligand …

Conventional magnetic resonance (MR) faces serious sensitivity limitations which can be
overcome by hyperpolarization methods, but the most common method (dynamic nuclear …

This article presents several covalent inhibitors, including examples of successful drugs, as
well as highly selective, irreversible inhibitors of emerging therapeutic targets, such as fatty …

The widespread applications of benzophenone (BP) photochemistry in biological chemistry,
bioorganic chemistry, and material science have been prominent in both academic and …

Protein kinases (PKs) play an important role in the development and progression of cancer
by regulating cell growth, survival, invasion, metastasis, and angiogenesis. Dasatinib (BMS …

γ-Secretase is an aspartyl intramembranal protease composed of presenilin, Nicastrin,
Aph1, and Pen2 with 19 transmembrane domains. γ-Secretase cleaves the amyloid …

J. Neurochem.(2012) 120 (Suppl. 1), 89–98. Abstract γ‐Secretase is a membrane
embedded aspartyl protease complex with presenilin as the catalytic component. Along with …

Photoaffinity labeling (PAL) in combination with a chemical probe to covalently bind its target
upon UV irradiation has demonstrated considerable promise in drug discovery for identifying …

Target identification of biologically active molecules such as natural products, synthetic
small molecules, peptides, and oligonucleotides mainly relies on affinity chromatography …