Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

Reactive oxygen species (ROS), a class of highly bioactive molecules, have been widely
studied in various types of cancers. ROS are considered to be normal byproducts of …

Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …

Anticancer metallodrugs based on ruthenium and osmium are among the most investigated
and advanced non-platinum metallodrugs. Inorganic drug discovery with these agents has …

Organometallic complexes containing ligands such as CO, carbenes, alkyls, phenyls, π-
bound alkynes, alkenes, cyclopentadienyls and arenes possess properties which have often …

As anticipated in the title, this contribution is basically divided into two, strictly connected,
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …

Metal complexes have been widely used for applications in the chemical and physical
sciences due to their unique electronic and stereochemical properties. For decades the use …

Excessive cellular oxidative stress is widely perceived as a key factor in pathophysiological
conditions and cancer development. Healthy cells use several mechanisms to maintain …