[HTML][HTML] New approaches to understanding the immune response to vaccination and infection
The immune system is a network of specialized cell types and tissues that communicates via
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …
Adjuvants in the driver's seat: how magnitude, type, fine specificity and longevity of immune responses are driven by distinct classes of immune potentiators
ES Bergmann-Leitner, WW Leitner - Vaccines, 2014 - mdpi.com
The mechanism by which vaccine adjuvants enhance immune responses has historically
been considered to be the creation of an antigen depot. From here, the antigen is slowly …
been considered to be the creation of an antigen depot. From here, the antigen is slowly …
Enteral nutrient deprivation in patients leads to a loss of intestinal epithelial barrier function
MW Ralls, FR Demehri, Y Feng, KMW Ignatoski… - Surgery, 2015 - Elsevier
Objective To investigate the effect of nutrient withdrawal on human intestinal epithelial
barrier function (EBF). We hypothesized that unfed mucosa results in decreased EBF. This …
barrier function (EBF). We hypothesized that unfed mucosa results in decreased EBF. This …
Human variation in DNA repair, immune function, and cancer risk
A Cheong, ZD Nagel - Frontiers in immunology, 2022 - frontiersin.org
DNA damage constantly threatens genome integrity, and DNA repair deficiency is
associated with increased cancer risk. An intuitive and widely accepted explanation for this …
associated with increased cancer risk. An intuitive and widely accepted explanation for this …
COVID-19: Mechanistic model of the african paradox supports the central role of the NF-κB pathway
R Kircheis, M Schuster, O Planz - Viruses, 2021 - mdpi.com
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has expanded
into a global pandemic, with more than 220 million affected persons and almost 4.6 million …
into a global pandemic, with more than 220 million affected persons and almost 4.6 million …
[HTML][HTML] Pattern recognition receptor-mediated cytokine response in infants across 4 continents⋆
KK Smolen, CE Ruck, ES Fortuno III, K Ho… - Journal of allergy and …, 2014 - Elsevier
Background Susceptibility to infection as well as response to vaccination varies among
populations. To date, the underlying mechanisms responsible for these clinical observations …
populations. To date, the underlying mechanisms responsible for these clinical observations …
Leveraging an existing whole‐genome resequencing population data set to characterize toll‐like receptor gene diversity in a threatened bird
Species recovery programs are increasingly using genomic data to measure neutral genetic
diversity and calculate metrics like relatedness. While these measures can inform …
diversity and calculate metrics like relatedness. While these measures can inform …
Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents
KK Smolen, B Cai, L Gelinas, ES Fortuno… - The Journal of …, 2014 - journals.aai.org
Innate immunity instructs adaptive immunity, and suppression of innate immunity is
associated with an increased risk for infection. We showed previously that whole-blood …
associated with an increased risk for infection. We showed previously that whole-blood …
Genetic Factors Altering Immune Responses in Atrial Fibrillation: JACC Review Topic of the Week
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide and is associated
with a range of adverse clinical outcomes. Accumulating evidence points to inflammatory …
with a range of adverse clinical outcomes. Accumulating evidence points to inflammatory …
Genetic variants in the TLR‐related pathway and smoking exposure alter the upper airway microbiota in adult asthmatic patients.
Abstract Keywords: asthma; genetics; microbiota; smoking EN asthma genetics microbiota
smoking 3217 3220 4 10/04/21 20211001 NES 211001 ACKNOWLEDGMENTS This work …
smoking 3217 3220 4 10/04/21 20211001 NES 211001 ACKNOWLEDGMENTS This work …