Immunization is a cornerstone of public health policy and is demonstrably highly cost-
effective when used to protect child health. Although it could be argued that immunology has …

Infectious diseases are a major driver of morbidity and mortality globally. Treatment of
malaria, tuberculosis and human immunodeficiency virus infection are particularly …

Background Malaria is a leading cause of morbidity and mortality worldwide. We previously
reported the efficacy of the R21/Matrix-M malaria vaccine, which reached the WHO-specified …

Background Stalled progress in controlling Plasmodium falciparum malaria highlights the
need for an effective and deployable vaccine. RTS, S/AS01, the most effective malaria …

Background Malaria control remains a challenge in many parts of the Sahel and sub-Sahel
regions of Africa. Methods We conducted an individually randomized, controlled trial to …

Vaccines can be highly effective tools in combating antimicrobial resistance as they reduce
infections caused by antibiotic-resistant bacteria and antibiotic consumption associated with …

Background CIS43LS is a monoclonal antibody that was shown to protect against controlled
Plasmodium falciparum infection in a phase 1 clinical trial. Whether a monoclonal antibody …

Background New approaches for the prevention and elimination of malaria, a leading cause
of illness and death among infants and young children globally, are needed. Methods We …

Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused
by pathogens, there are still known diseases and emerging pathogens for which the …

Background Additional interventions are needed to reduce the morbidity and mortality
caused by malaria. Methods We conducted a two-part, phase 1 clinical trial to assess the …