Malaria is an illness caused by Plasmodium parasites transmitted to humans by infected
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …

Despite the overwhelming success of vaccines in preventing infectious diseases, there
remain numerous globally devastating diseases without fully protective vaccines, particularly …

Background Malaria is a leading cause of morbidity and mortality worldwide. We previously
reported the efficacy of the R21/Matrix-M malaria vaccine, which reached the WHO-specified …

Background Stalled progress in controlling Plasmodium falciparum malaria highlights the
need for an effective and deployable vaccine. RTS, S/AS01, the most effective malaria …

Background Malaria control remains a challenge in many parts of the Sahel and sub-Sahel
regions of Africa. Methods We conducted an individually randomized, controlled trial to …

Background CIS43LS is a monoclonal antibody that was shown to protect against controlled
Plasmodium falciparum infection in a phase 1 clinical trial. Whether a monoclonal antibody …

Background New approaches for the prevention and elimination of malaria, a leading cause
of illness and death among infants and young children globally, are needed. Methods We …

Background Additional interventions are needed to reduce the morbidity and mortality
caused by malaria. Methods We conducted a two-part, phase 1 clinical trial to assess the …

Executive summary 50 years after a noble but flawed attempt to eradicate malaria in the mid-
20th century, the global malaria community is once again seriously considering eradication …

Malaria cases and deaths remain unacceptably high and are resurgent in several settings,
though recent developments inspire optimism. This includes the approval of the world's first …