Update on the pathogenesis of chronic obstructive pulmonary disease

A Agustí, JC Hogg - New England Journal of Medicine, 2019 - Mass Medical Soc
Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology

M Eslam, J George - Nature reviews Gastroenterology & hepatology, 2020 - nature.com
Nonalcoholic fatty liver disease (NAFLD) affects around a quarter of the global population,
paralleling worldwide increases in obesity and metabolic syndrome. NAFLD arises in the …

Definition and nomenclature of chronic obstructive pulmonary disease: time for its revision

B Celli, L Fabbri, G Criner, FJ Martinez… - American journal of …, 2022 - atsjournals.org
Attempts to define concepts and things date back to the time of Aristotle, around 2,400 years
ago, when he proposed that a definition should state the essential nature or being of …

Objectives, design and main findings until 2020 from the Rotterdam Study

MA Ikram, G Brusselle, M Ghanbari… - European journal of …, 2020 - Springer
Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

PG Miller, D Qiao, J Rojas-Quintero… - Blood, The Journal …, 2022 - ashpublications.org
Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but
other determinants of the disease are incompletely understood. Clonal hematopoiesis of …

Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models

J Cosentino, B Behsaz, B Alipanahi, ZR McCaw… - Nature Genetics, 2023 - nature.com
Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide,
is highly heritable. While COPD is clinically defined by applying thresholds to summary …

Syndrome of combined pulmonary fibrosis and emphysema: an official ATS/ERS/JRS/ALAT research statement

V Cottin, M Selman, Y Inoue, AW Wong… - American journal of …, 2022 - atsjournals.org
Background: The presence of emphysema is relatively common in patients with fibrotic
interstitial lung disease. This has been designated combined pulmonary fibrosis and …

The Rotterdam Study: 2018 update on objectives, design and main results

MA Ikram, GGO Brusselle, SD Murad… - European journal of …, 2017 - Springer
Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

N Shrine, AL Guyatt, AM Erzurumluoglu, VE Jackson… - Nature …, 2019 - nature.com
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder

MH Cho, BD Hobbs, EK Silverman - The Lancet Respiratory …, 2022 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease.
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …