Movement, cognition and perception arise from the collective activity of neurons within
cortical circuits and across large-scale systems of the brain. While the causes of single …

Cognitive function requires the coordination of neural activity across many scales, from
neurons and circuits to large-scale networks. As such, it is unlikely that an explanatory …

Seizures can occur spontaneously and in a recurrent manner, which defines epilepsy; or
they can be induced in a normal brain under a variety of conditions in most neuronal …

The human brain has the capacity to rapidly change state, and in epilepsy these state
changes can be catastrophic, resulting in loss of consciousness, injury and even death …

A broad body of experimental work has demonstrated that apparently spontaneous brain
activity is not random. At the level of large-scale neural systems, as measured with functional …

Recent years of research have shown that the complex temporal structure of ongoing
oscillations is scale-free and characterized by long-range temporal correlations. Detrended …

We present The Virtual Brain (TVB), a neuroinformatics platform for full brain network
simulations using biologically realistic connectivity. This simulation environment enables the …

Abstract See Eissa and Schevon (doi: 10.1093/aww332) for a scientific commentary on this
article. Surgery can be a last resort for patients with intractable, medically refractory epilepsy …

In this article, we describe the mathematical framework of the computational model at the
core of the tool The Virtual Brain (TVB), designed to simulate collective whole brain …

The cortex is a complex system, characterized by its dynamics and architecture, which
underlie many functions such as action, perception, learning, language, and cognition. Its …