The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Although angiotensin II (AngII) is known to cause renal injury and fibrosis, the underlying
mechanisms remain poorly characterized. Here we show that hypertensive nephropathy …

Biomarkers for the identification of diabetic kidney disease (DKD) are needed as current
tests lack sensitivity for detecting early kidney damage. MicroRNAs (miRNAs) are short, non …

Substantial evidence indicates that microRNA-155 (miR-155) plays a crucial role in the
pathogenesis of diabetes mellitus (DM) and its complications. A number of clinical studies …

Diabetic nephropathy (DN) is a research priority for scientists around the world because of
its high prevalence and poor prognosis. Although several mechanisms have been shown to …

The most classical view of the renin-angiotensin system (RAS) emphasizes its role as an
endocrine regulator of sodium balance and blood pressure. However, it has long become …

Diabetic Nephropathy (DN) is a chronic complication of diabetes and the primary cause of
end stage renal disease. Differential diagnosis for DN requires invasive histological …

Background Diabetic kidney disease is a renal microvascular disease caused by diabetes,
known as one of the most serious and lethal complications of diabetes. Early renal …

Big data are a major driver in the development of precision medicine. Efficient analysis
methods are needed to transform big data into clinically-actionable knowledge. To …