Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring

M Denizli, ML Capitano, KL Kua - Frontiers in cellular and infection …, 2022 - frontiersin.org
The prevalence of obesity is increasingly common in the United States, with~ 25% of women
of reproductive age being overweight or obese. Metaflammation, a chronic low grade …

Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia

DE Surate Solaligue… - … of Physiology-Lung …, 2017 - journals.physiology.org
The objective of lung development is to generate an organ of gas exchange that provides
both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly …

Persistent pulmonary hypertension of the newborn: pathophysiological mechanisms and novel therapeutic approaches

S Martinho, R Adão, AF Leite-Moreira… - Frontiers in …, 2020 - frontiersin.org
Persistent pulmonary hypertension of the newborn (PPHN) is one of the main causes of
neonatal morbidity and mortality. It is characterized by sustained elevation of pulmonary …

Obesity and the development of lung fibrosis

X Guo, C Sunil, G Qian - Frontiers in pharmacology, 2022 - frontiersin.org
Obesity is an epidemic worldwide and the obese people suffer from a range of respiratory
complications including fibrotic changes in the lung. The influence of obesity on the lung is …

Maternal obesity mediated predisposition to respiratory complications at birth and in later life: understanding the implications of the obesogenic intrauterine …

EV McGillick, MC Lock, S Orgeig, JL Morrison - Paediatric respiratory …, 2017 - Elsevier
More women than not are entering pregnancy either overweight or obese. This presents a
significant health care burden with respect to maternal morbidities and offspring …

Mitochondrial transfer improves cardiomyocyte bioenergetics and viability in male rats exposed to pregestational diabetes

EJ Louwagie, TD Larsen, AL Wachal… - International journal of …, 2021 - mdpi.com
Offspring born to diabetic or obese mothers have a higher lifetime risk of heart disease.
Previously, we found that rat offspring exposed to late-gestational diabetes mellitus (LGDM) …

Diabetic pregnancy and maternal high-fat diet impair mitochondrial dynamism in the developing fetal rat heart by sex-specific mechanisms

TD Larsen, KH Sabey, AJ Knutson, TCT Gandy… - International journal of …, 2019 - mdpi.com
Infants born to diabetic or obese mothers are at greater risk of heart disease at birth and
throughout life, but prevention is hindered because underlying mechanisms remain poorly …

Application of ultrasound‐based radiomics technology in fetal‐lung‐texture analysis in pregnancies complicated by gestational diabetes and/or pre‐eclampsia

Y Du, Z Fang, J Jiao, G Xi, C Zhu, Y Ren… - … in Obstetrics & …, 2021 - Wiley Online Library
Objectives To analyze and compare, using ultrasound‐based radiomics technology, fetal‐
lung texture in pregnancies affected by gestational diabetes mellitus (GDM) and/or pre …

Establish a normal fetal lung gestational age grading model and explore the potential value of deep learning algorithms in fetal lung maturity evaluation

TH Xia, M Tan, JH Li, JJ Wang, QQ Wu… - Chinese Medical …, 2021 - mednexus.org
Background: Prenatal evaluation of fetal lung maturity (FLM) is a challenge, and an effective
non-invasive method for prenatal assessment of FLM is needed. The study aimed to …

Prenatal exposure to a maternal high-fat diet affects histone modification of cardiometabolic genes in newborn rats

B Upadhyaya, T Larsen, S Barwari, EJ Louwagie… - Nutrients, 2017 - mdpi.com
Infants born to women with diabetes or obesity are exposed to excess circulating fuels
during fetal heart development and are at higher risk of cardiac diseases. We have …