Intracranial pressure monitoring (ICP) is based on the doctrine proposed by Monroe and
Kellie centuries ago. With the advancement of technology and science, various invasive and …

Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Objectives: A relationship between reduced brain tissue oxygenation and poor outcome
following severe traumatic brain injury has been reported in observational studies. We …

Microdialysis enables the chemistry of the extracellular interstitial space to be monitored.
Use of this technique in patients with acute brain injury has increased our understanding of …

Objectives: Research suggests that the majority of mild traumatic brain injury (mTBI) patients
exhibit both cognitive and emotional dysfunction within the first weeks of injury, followed by …

Intracranial pressure (ICP) monitoring is a staple of neurocritical care. The most commonly
used current methods of monitoring in the acute setting include fluid-based systems …

Objective Traumatic brain injury (TBI) results in persistent disruption of brain metabolism that
has yet to be mechanistically defined. Early post‐traumatic seizures are one potential …

Secondary insults can adversely influence outcome following severe traumatic brain injury.
Monitoring of cerebral extracellular chemistry with microdialysis has the potential for early …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …