[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

Effects of β-Blockers on the Sympathetic and Cytokines Storms in Covid-19

HM Al-Kuraishy, AI Al-Gareeb… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative virus in the
development of coronavirus disease 2019 (Covid-19) pandemic. Respiratory manifestations …

Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei

A Emmi, S Rizzo, L Barzon, M Sandre… - npj Parkinson's …, 2023 - nature.com
Neurological manifestations are common in COVID-19, the disease caused by SARS-CoV-
2. Despite reports of SARS-CoV-2 detection in the brain and cerebrospinal fluid of COVID …

Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation

AJ Turner, NN Nalivaeva - Peptides, 2022 - Elsevier
Abstract Angiotensin-converting enzyme-2, or ACE2, is primarily a zinc-dependent
peptidase and ectoenzyme expressed in numerous cell types and functioning as a …

Control of breathing

JA Dempsey, JF Welch - Seminars in respiratory and critical …, 2023 - thieme-connect.com
Substantial advances have been made recently into the discovery of fundamental
mechanisms underlying the neural control of breathing and even some inroads into …

Multiple aspects of inappropriate action of renin–angiotensin, vasopressin, and oxytocin systems in neuropsychiatric and neurodegenerative diseases

E Szczepanska-Sadowska, A Wsol… - Journal of Clinical …, 2022 - mdpi.com
The cardiovascular system and the central nervous system (CNS) closely cooperate in the
regulation of primary vital functions. The autonomic nervous system and several compounds …

[HTML][HTML] Case report: the carotid body in COVID-19: histopathological and virological analyses of an autopsy case series

A Porzionato, A Emmi, M Contran, E Stocco… - Frontiers in …, 2021 - frontiersin.org
Various authors have hypothesized carotid body (CB) involvement in Coronavirus Disease
2019 (COVID-19), through direct invasion or indirect effects by systemic stimuli ('cytokine …

Silent hypoxia in COVID-19: a gut microbiota connection

AB Gopal, S Chakraborty, PK Padhan, A Barik… - Current opinion in …, 2021 - Elsevier
Highlights•SARS-CoV-2-mediated gut dysbiosis disrupts production of SCFA and other
metabolites.•Dysbiosis causes inflammation and intestinal barrier as well as blood-brain …

Potential mechanisms underlying COVID-19-mediated central and peripheral demyelination: Roles of the RAAS and ADAM-17

KB Oliveira, FMA de Souza, LBM de Sá… - Molecular …, 2024 - Springer
Demyelination is among the most conspicuous neurological sequelae of SARS-CoV-2
infection (COVID-19) in both the central (CNS) and peripheral (PNS) nervous systems …

Post-COVID breathlessness: a mathematical model of respiratory processing in the brain

D von Werder, F Regnath, D Schäfer, R Jörres… - European Archives of …, 2024 - Springer
Breathlessness is among the most common post-COVID symptoms. In a considerable
number of patients, severe breathlessness cannot be explained by peripheral organ …