The rapid and accurate in silico prediction of protein-ligand binding free energies or binding
affinities has the potential to transform drug discovery. In recent years, there has been a …

Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer
patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the …

The co‐occurrence of cancer and heart failure (HF) represents a significant clinical
drawback as each disease interferes with the treatment of the other. In addition to shared …

Adipose tissue represents a critical component in healthy energy homeostasis. It fulfills
important roles in whole‐body lipid handling, serves as the body's major energy storage …

Cancer cachexia is a multifactorial condition characterized by body weight loss that
negatively affects quality of life and survival of patients with cancer. Despite the clinical …

Cancer cachexia (CC) is a multifactorial syndrome in patients with advanced cancer
characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic …

Cachexia is a wasting disorder that accompanies many chronic diseases including cancer
and results from an imbalance of energy requirements and energy uptake. In cancer …

Cachexia represents a fatal energy-wasting syndrome in a large number of patients with
cancer that mostly results in a pathological loss of skeletal muscle and adipose tissue. Here …

Objective Single-nucleotide polymorphisms in the FTO gene encoding an m 6 Am and an m
6 A demethylase are associated with obesity. Moreover, recent studies have linked a …

Cancer cachexia, or progressive weight loss, often despite adequate nutrition contributes
greatly to cancer morbidity and mortality. Cachexia is metabolically distinct from starvation or …