The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as
a blocker of an emerging class of human intracellular channels, namely the two-pore …

Soil salinity is destroying arable land and is considered to be one of the major threats to
global food security in the 21st century. Therefore, the ability of naturally salt-tolerant …

A distinct set of channels and transporters regulates the ion fluxes across the lysosomal
membrane. Malfunctioning of these transport proteins and the resulting ionic imbalance is …

The chloride-proton exchanger CLC-7 plays critical roles in lysosomal homeostasis and
bone regeneration and its mutation can lead to osteopetrosis, lysosomal storage disease …

Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging
class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by …

Eukaryotic anion/proton exchangers of the CLC (chloride channel) family mediate anion
fluxes across intracellular membranes. The Arabidopsis thaliana anion/proton exchanger …

Two-pore channel proteins (TPC) encode intracellular ion channels in both animals and
plants. In mammalian cells, the two isoforms (TPC1 and TPC2) localize to the endo …

Two-pore channels (TPC) are intracellular endo-lysosomal proteins with only recently
emerging roles in organellar signalling and involvement in severe human diseases. Here …

Nitrate is a major nutrient and osmoticum for plants. To deal with fluctuating nitrate
availability in soils, plants store this nutrient in their vacuoles. Chloride channel a (CLCa), a …

Abstract Phosphatidylinositol‐3, 5‐bisphosphate (PI (3, 5) P2) is a low‐abundance signaling
lipid associated with endo‐lysosomal and vacuolar membranes in eukaryotic cells. Recent …