An Active Site Tyr Residue Guides the Regioselectivity of Lysine Hydroxylation by Nonheme Iron Lysine-4-hydroxylase Enzymes through Proton-Coupled Electron …
Y Cao, S Hay, SP de Visser - Journal of the American Chemical …, 2024 - ACS Publications
Lysine dioxygenase (KDO) is an important enzyme in human physiology involved in
bioprocesses that trigger collagen cross-linking and blood pressure control. There are …
bioprocesses that trigger collagen cross-linking and blood pressure control. There are …
An α-ketoglutarate conformational switch controls iron accessibility, activation, and substrate selection of the human FTO protein
The fat mass and obesity-associated fatso (FTO) protein is a member of the Alkb family of
dioxygenases and catalyzes oxidative demethylation of N6-methyladenosine (m6A), N1 …
dioxygenases and catalyzes oxidative demethylation of N6-methyladenosine (m6A), N1 …
The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe (II)/2-Oxoglutarate Histone Demethylase KDM2A
MG Thomas, SB Jaber Sathik Rifayee… - Inorganic …, 2024 - ACS Publications
Nonheme Fe (II) and 2-oxoglutarate (2OG)-dependent histone lysine demethylases 2A
(KDM2A) catalyze the demethylation of the mono-or dimethylated lysine 36 residue in the …
(KDM2A) catalyze the demethylation of the mono-or dimethylated lysine 36 residue in the …
Mechanism of Peroxynitrite Interaction with Ferric M. tuberculosis Nitrobindin: A Computational Study
A Messias, L Capece, G De Simone, M Coletta… - Inorganic …, 2024 - ACS Publications
Nitrobindins (Nbs) are all-β-barrel heme proteins present along the evolutionary ladder.
They display a highly solvent-exposed ferric heme group with the iron atom being …
They display a highly solvent-exposed ferric heme group with the iron atom being …
Theoretical investigation of the reaction mechanism of THP oxidative rearrangement catalysed by BBOX
F Meng, L Sun, Y Liu, X Li, H Tan, C Yuan… - Physical Chemistry …, 2024 - pubs.rsc.org
γ-Butyrobetaine hydroxylase (BBOX) is a non-heme FeII/2OG dependent enzyme that is
able to perform two different kinds of catalytic reactions on 3-(2, 2, 2-trimethylhydrazinium) …
able to perform two different kinds of catalytic reactions on 3-(2, 2, 2-trimethylhydrazinium) …
Detailed computational analysis reveals the molecular basis of FTO catalysis
In this issue of Chem Catalysis, Karabencheva-Christova and co-workers report the
mechanistic elucidation of fat-mass and obesity-associated enzyme (FTO). Through …
mechanistic elucidation of fat-mass and obesity-associated enzyme (FTO). Through …