Pediatric Acute Lymphoblastic Leukemia (ALL) cure rates have improved exponentially over
the past five decades with now over 90% of children achieving long-term survival. A direct …

Cephalosporins are commonly used antibiotics both in hospitalized patients and in
outpatients. Hypersensitivity reactions to cephalosporins are becoming increasingly …

Resolving conflict of interest The Joint Task Force on Practice Parameters (JTFPP) is
committed to ensuring that all guidelines are based on the best scientific evidence at the …

Background l-asparaginase is a universal component of treatment for childhood acute
lymphoblastic leukaemia, and is usually administered intramuscularly. Pegylated …

Background Hereditary predisposition is rarely suspected for childhood acute lymphoblastic
leukaemia (ALL). Recent reports of germline ETV6 variations associated with substantial …

Purpose Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly
penetrant cancer predisposition condition. Recent reports of germline TP53 variants in …

Individuals differ substantially in their response to pharmacological treatment. Personalized
medicine aspires to embrace these inter-individual differences and customize therapy by …

Prolonged exposure to thiopurines (eg, mercaptopurine [MP]) is essential for curative
therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose …

PURPOSE Pegaspargase (PEG-ASP) has largely replaced native Escherichia coli
asparaginase (L-ASP) in the treatment of acute lymphoblastic leukemia because of its …

Asparaginase is commonly used in combination therapy of acute lymphoblastic leukemia.
However, as an immunogenic protein, hypersensitivity reactions (HSRs) during …