Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of gene expression,
contributing significantly to a diverse range of cellular processes, including apoptosis. One …

Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …

The human genome is pervasively transcribed, producing a majority of short and long
noncoding RNAs (lncRNAs) that can influence cellular programs through a variety of …

Long noncoding RNAs (lncRNAs) are sequences of 200 nucleotides or more that are
transcribed from a large portion of the mammalian genome. While hypothesized to have a …

Paraspeckles are nuclear condensates, or membranelees organelles, that are built on the
long noncoding RNA, NEAT1, and have been linked to many diseases. Although originally …

Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is
known to confer cytoplasmic gain of function but its effects in the nucleus are less …

NEAT1 is a highly abundant nuclear architectural long non-coding RNA. There are two
overlapping NEAT1 isoforms, NEAT1_1 and NEAT1_2, of which the latter is an essential …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

Recent advances in RNA sequencing technologies helped to uncover the existence of tens
of thousands of long non-coding RNAs (lncRNAs) that arise from the dark matter of the …