Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus
challenge the long-standing hypothesis that hippocampal long-term potentiation-like …

The synaptic plasticity and memory hypothesis asserts that activity-dependent synaptic
plasticity is induced at appropriate synapses during memory formation and is both …

The ability to change behavior likely depends on the selective strengthening and weakening
of brain synapses. The cellular models of synaptic plasticity, long-term potentiation (LTP) …

Schizophrenia is a severe chronic psychiatric illness, characterized by hallucinations and
delusions. Decreased brain volumes have been observed in the disease, although the …

It is humbling to think that 30 years have passed since the paper by Collingridge, Kehl and
McLennan showing that one of Jeff Watkins most interesting compounds, R-2-amino-5 …

N-Methyl-d-aspartate receptor (NMDAR)-dependent synaptic plasticity is a strong candidate
to mediate learning and memory processes that require the hippocampus. This plasticity is …

Involvement of the glutamate system, particularly N-methyl-D-aspartate (NMDA) receptor
hypofunction, has long been postulated to be part of the pathophysiology of schizophrenia …

NMDA receptors (NMDARs) are key mediators of certain forms of synaptic plasticity and
learning. NMDAR complexes are heteromers composed of an obligatory GluN1 subunit and …