CB1 and CB2 receptors are activated by a plethora of cannabinoid compounds, be they
endogenously‐produced, plant‐derived or synthetic. These receptors are expressed by …

The endocannabinoid system consists of the endogenous cannabinoids
(endocannabinoids), cannabinoid receptors and the enzymes that synthesise and degrade …

As our understanding of the endocannabinoids improves, so does the awareness of their
complexity. During pathological states, the levels of these mediators in tissues change, and …

The endocannabinoid system was revealed following the understanding of the mechanism
of action of marijuana's major psychotropic principle, Δ 9-tetrahydrocannabinol, and …

Cannabinoids can influence the immune network. Data on the impact of exogenous
cannabinoid ligands on immune function serve not only to understand how the …

A rather complex and pleiotropic endogenous signalling system was discovered in the late
1990s, starting from studies on the mechanism of action of Δ9-tetrahydrocannabinol, the …

The molecular mechanism of action of Δ 9-tetrahydrocannabinol (THC), the psychotropic
constituent of Cannabis, has been a puzzle during the three decades separating its …

The endocannabinoid system is represented by a group of neuromodulatory lipids and their
receptors that are involved in a variety of physiological and pathological conditions. The …

Nicotinic acetylcholine receptors (nAChRs) are receptors for the neurotransmitter
acetylcholine and are members of the 'Cys-loop'family of pentameric ligand-gated ion …

To date, it has been thought that cannabinoid receptors in CNS are primarily of the CB1R
subtype, with CB2R expressed only in glia and peripheral tissues. However, evidence for …