Homologous recombination enables the cell to access and copy intact DNA sequence
information in trans, particularly to repair DNA damage affecting both strands of the double …

▪ Abstract The primary function of bacterial recombination systems is the nonmutagenic
repair of stalled or collapsed replication forks. The RecA protein plays a central role in these …

To clarify RAD51 interactions controlling homologous recombination, we report here the
crystal structure of the full‐length RAD51 homolog from Pyrococcus furiosus. The structure …

Both the bacterial RecA protein and the eukaryotic Rad51 protein form helical nucleoprotein
filaments on DNA that catalyze strand transfer between two homologous DNA molecules …

The strand-exchange reaction is central to homologous recombination. It is catalysed by the
RecA family of ATPases, which form a helical filament with single-stranded DNA (ssDNA) …

Homologous recombination (HR) uses a homologous template to accurately repair DNA
double-strand breaks and stalled replication forks to maintain genome stability. During …

Human Rad51 protein (HsRad51) is a homolog of Escherichia coli RecA protein, and
functions in DNA repair and recombination. In higher eukaryotes, Rad51 protein is essential …

The bacterial RecA protein participates in a remarkably diverse set of functions, all of which
are involved in the maintenance of genomic integrity. RecA is a central component in both …

Germ-line mutations in BRCA2 account for approximately half the cases of autosomal
dominant familial breast cancers. BRCA2 has been shown to interact directly with RAD51 …

The crystal structure of the E. coli RecA protein was solved more than 10 years ago, but it
has provided limited insight into the mechanism of homologous genetic recombination …