[PDF][PDF] Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia but has no effective
treatment. A comprehensive investigation of cell type-specific responses and cellular …
treatment. A comprehensive investigation of cell type-specific responses and cellular …
[PDF][PDF] Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate?
The notion of exploiting the regenerative potential of the human brain in physiological aging
or neurological diseases represents a particularly attractive alternative to conventional …
or neurological diseases represents a particularly attractive alternative to conventional …
Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer's disease brain
Background Mitochondrial dysfunction is a feature of neurodegenerative diseases, including
Alzheimer's disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and …
Alzheimer's disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and …
VGF as a biomarker and therapeutic target in neurodegenerative and psychiatric diseases
JP Quinn, SE Kandigian, BA Trombetta… - Brain …, 2021 - academic.oup.com
Neurosecretory protein VGF (non-acronymic) belongs to the granin family of neuropeptides.
VGF and VGF-derived peptides have been repeatedly identified in well-powered and well …
VGF and VGF-derived peptides have been repeatedly identified in well-powered and well …
Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease
Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …
Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations
Microglia have fundamental roles in health and disease; however, effects of age, sex, and
genetic factors on human microglia have not been fully explored. We applied bulk and …
genetic factors on human microglia have not been fully explored. We applied bulk and …
Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease
The risk of developing Alzheimer's disease (AD) significantly increases in individuals
carrying the APOEε4 allele. Elderly cognitively healthy individuals with APOEε4 also exist …
carrying the APOEε4 allele. Elderly cognitively healthy individuals with APOEε4 also exist …
Alzheimer's disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions
Vast numbers of differentially expressed genes and perturbed networks have been identified
in Alzheimer's disease (AD), however, neither disease nor brain region specificity of these …
in Alzheimer's disease (AD), however, neither disease nor brain region specificity of these …