The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
S Cambier, M Gouwy, P Proost - Cellular & Molecular Immunology, 2023 - nature.com
Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …
of directional migration and activation of leukocytes. CXCL8 is the most potent human …
The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases
Chemokines are small proteins that control several tissue functions, including cell
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …
Matrix metalloproteinases in COPD
A Churg, S Zhou, JL Wright - European Respiratory Journal, 2012 - Eur Respiratory Soc
There is considerable evidence that matrix metalloproteinases (MMPs) are up-and/or
downregulated in chronic obstructive pulmonary disease (COPD), particularly in …
downregulated in chronic obstructive pulmonary disease (COPD), particularly in …
CXCR2 antagonist MK-7123. A phase 2 proof-of-concept trial for chronic obstructive pulmonary disease
SI Rennard, DC Dale, JF Donohue… - American journal of …, 2015 - atsjournals.org
Rationale: An antagonist (MK-7123) of the cytokine receptor CXCR2 reduces neutrophil
chemotaxis and thus may alleviate airway inflammation in chronic obstructive pulmonary …
chemotaxis and thus may alleviate airway inflammation in chronic obstructive pulmonary …
Inhibition of PI3Kδ restores glucocorticoid function in smoking-induced airway inflammation in mice
JA Marwick, G Caramori, CS Stevenson… - American journal of …, 2009 - atsjournals.org
Rationale: There is an increasing prevalence of reduced responsiveness to glucocorticoid
therapy in severe asthma and chronic obstructive pulmonary disease (COPD). The …
therapy in severe asthma and chronic obstructive pulmonary disease (COPD). The …
Chemokines in COPD: from implication to therapeutic use
Chronic Obstructive Pulmonary Disease (COPD) represents the 3rd leading cause of death
in the world. The underlying pathophysiological mechanisms have been the focus of …
in the world. The underlying pathophysiological mechanisms have been the focus of …
CXCR2: from bench to bedside
A Stadtmann, A Zarbock - Frontiers in immunology, 2012 - frontiersin.org
Leukocyte recruitment to sites of infection or tissue damage plays a crucial role for the innate
immune response. Chemokine-dependent signaling in immune cells is a very important …
immune response. Chemokine-dependent signaling in immune cells is a very important …
The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research
Chronic obstructive pulmonary disease (COPD) progression is characterized by
accumulation of inflammatory mucous exudates in the lumens of small airways, and …
accumulation of inflammatory mucous exudates in the lumens of small airways, and …
ELR+ CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets
C Bizzarri, AR Beccari, R Bertini, MR Cavicchia… - Pharmacology & …, 2006 - Elsevier
ELR+ CXC chemokines, by direct interaction with their cell surface receptors CXC
chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2), are believed to …
chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2), are believed to …
CXCR2 antagonists for the treatment of pulmonary disease
RW Chapman, JE Phillips, RW Hipkin… - Pharmacology & …, 2009 - Elsevier
Chemokines have long been implicated in the initiation and amplification of inflammatory
responses by virtue of their role in leukocyte chemotaxis. The expression of one of the …
responses by virtue of their role in leukocyte chemotaxis. The expression of one of the …