Iron‑sulfur clusters (Fesingle bond S) are one of the most primitive and ubiquitous cofactors
used by various enzymes in multiple pathways. Biosynthesis of Fe single bond S is a …

Acute liver failure (ALF) is a rare, rapidly evolving, clinical syndrome with devastating
consequences where definitive treatment is by emergency liver transplantation. Establishing …

Dihydrolipoamide dehydrogenase (DLD) deficiency is an ultra‐rare autosomal‐recessive
inborn error of metabolism, affecting no less than five mitochondrial multienzyme complexes …

Chronic kidney disease (CKD) impacts 14% of adults in the United States, and African
American (AA) individuals are disproportionately affected, with more than 3 times higher risk …

Abstract Ferredoxin‐2 (FDX2) is an electron transport protein required for iron–sulfur
clusters biosynthesis. Pathogenic variants in FDX2 have been associated with autosomal …

The present work delves into the enigmatic world of mitochondrial alpha-keto acid
dehydrogenase complexes discussing their metabolic significance, enzymatic operation …

Dihydrolipoamide dehydrogenase (DLD) deficiency can, in one of its forms, be a rare cause
of acute liver failure. Clinical presentation is nonspecific. Biochemical findings can reflect …

Maple syrup urine disease (MSUD) is a rare metabolic disorder that is caused by mutations
in the branched chain alpha keto acid dehydrogenase enzyme complex (BCKDC). There …