Objective: Piperacillin-tazobactam is a commonly used antibiotic in critically ill patients;
however, controversy exists as to whether mortality in serious infections can be decreased …

Mortality and morbidity in severe sepsis and septic shock remain high despite significant
advances in critical care. Efforts to improve outcome in septic conditions have focused on …

Background Recently, continuous administration of piperacillin-tazobactam has been
proposed as a valuable alternative to traditional intermittent administration especially in …

The scope of TDM is broadening from the traditional focus on prevention of toxicity, to
include optimization of antibiotic exposure thereby improving patient outcomes. However …

Introduction: Beta-lactams are at the cornerstone of therapy in critical care settings, but their
clinical efficacy is challenged by the rise in bacterial resistance. Infections with multi-drug …

What is known and objective The role of continuous/extended beta‐lactam infusions (CEIs)
in improving clinical outcomes among critically ill patients remains controversial. Therefore …

Background: Sporadic studies in antimicrobial therapy have evaluated the effects of infusion
rates on therapeutic and economic outcomes, and new findings may challenge the regular …

Purpose Pseudomonas aeruginosa is a commonly isolated nosocomial pathogen for which
treatment options are often limited for multidrug-resistant isolates. In addition to newer …

Background: Current medical center practice allows for the automatic conversion of all
piperacillin/tazobactam orders from intermittent to extended infusion (EI). Objective: To …

This study aimed to characterize the population pharmacokinetics (PKs) of piperacillin and
investigate probability of target attainment (PTA) and cumulative fraction of response (CFR) …