Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
B Nilius, A Szallasi - Pharmacological reviews, 2014 - ASPET
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
[HTML][HTML] Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain
Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …
[HTML][HTML] TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway
Z Lv, X Xu, Z Sun, YX Yang, H Guo, J Li, K Sun… - Cell death & …, 2021 - nature.com
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven
synovitis exacerbates the pathological process. However, precise therapies for M1 …
synovitis exacerbates the pathological process. However, precise therapies for M1 …
[HTML][HTML] Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis
HT Philpott, M O'Brien, JJ McDougall - Pain, 2017 - journals.lww.com
Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration,
intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a noneuphoria …
intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a noneuphoria …
[HTML][HTML] Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases
B Mailhot, M Christin, N Tessandier… - Journal of Experimental …, 2020 - rupress.org
Chronic pain is a major comorbidity of chronic inflammatory diseases. Here, we report that
the cytokine IL-1β, which is abundantly produced during multiple sclerosis (MS), arthritis …
the cytokine IL-1β, which is abundantly produced during multiple sclerosis (MS), arthritis …
What is the evidence for the role of TRP channels in inflammatory and immune cells?
A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …
responses. Among these, the cation channels of the transient receptor potential (TRP) family …
Mechanosensitive TRPV4 is required for crystal-induced inflammation
Crystal structures activate innate immune cells, especially macrophages and initiate
inflammatory responses. We aimed to understand the role of the mechanosensitive TRPV4 …
inflammatory responses. We aimed to understand the role of the mechanosensitive TRPV4 …
Sensory TRP channels: the key transducers of nociception and pain
Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a
complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve …
complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve …
[HTML][HTML] Nociceptive TRP channels: sensory detectors and transducers in multiple pain pathologies
Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-
gated ion channels constitute the critical detectors and transducers of pain-causing stimuli …
gated ion channels constitute the critical detectors and transducers of pain-causing stimuli …
Medicinal chemistry, pharmacology, and clinical implications of TRPV1 receptor antagonists
M Aghazadeh Tabrizi, PG Baraldi… - Medicinal research …, 2017 - Wiley Online Library
Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory
neurons triggering an influx of cations. TRPV1 receptors function as homotetramers …
neurons triggering an influx of cations. TRPV1 receptors function as homotetramers …