Background The human gut hosts complex microbial communities, which are linked to
health and disease. The gut microbiota is continuously reshaped by multiple environmental …

First designed and published in 1998 as a laboratory tool to study Myc perturbation,
Omomyc has come a long way in the past 22 years. This dominant negative has contributed …

Intestinal organoids capture essential features of the intestinal epithelium such as crypt
folding, cellular compartmentalization and collective movements. Each of these processes …

Steady-state turnover is a hallmark of epithelial tissues throughout adult life. Intestinal
epithelial turnover is marked by continuous cell migration, which is assumed to be driven by …

Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …

The intestinal epithelial barrier protects the mucosa of the gastrointestinal (GI)-tract and
plays a key role in maintaining the host homeostasis. It encompasses several elements that …

The gut barrier acts as a first line of defense in the body, and plays a vital role in nutrition
and immunoregulation. A layer of epithelial cells bound together via intercellular junction …

Background and Aims Gut bacteria-derived short-chain fatty acids (SCFAs) play crucial roles
in the maintenance of intestinal homeostasis. However, how SCFAs regulate epithelial …

Summary Polycomb repressive complex 2 (PRC2) places H3K27me3 at developmental
genes and is causally implicated in keeping bivalent genes silent. It is unclear if that silence …

The gastrointestinal tract is a highly complex organ in which multiple dynamic physiological
processes are tightly coordinated while interacting with a dense and extremely diverse …