G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …

G-protein-coupled receptors (GPCRs) are the largest and most versatile cell surface
receptor family with a broad repertoire of ligands and functions. We've learned an enormous …

Summary Hydroxycarboxylic acid receptor 2 (HCAR2), modulated by endogenous ketone
body β-hydroxybutyrate and exogenous niacin, is a promising therapeutic target for …

Hydroxycarboxylic acids are crucial metabolic intermediates involved in various
physiological and pathological processes, some of which are recognized by specific …

Allosteric drugs offer a new avenue for modern drug design. However, the identification of
cryptic allosteric sites presents a formidable challenge. Following the allostery nature of …

Cannabis sativa is known for its therapeutic benefit in various diseases including pain relief
by targeting cannabinoid receptors. The primary component of cannabis, Δ9 …

Abstract Hydroxycarboxylic acid receptor 2 (HCAR2), a member of Class A G-protein-
coupled receptor (GPCR) family, plays a pivotal role in anti-lipolytic and anti-inflammatory …

Modular proteins are regulatory proteins that carry out more than one function. These
proteins upregulate or downregulate a biochemical cascade to establish homeostasis in …

Despite advances in chemical, computational and biological sciences, the rate of attrition of
drug candidates in clinical development is still high. A key point in the small-molecule …

Abstract 'Globesity'is a foremost challenge to the healthcare system. The limited efficacy and
adverse effects of available oral pharmacotherapies pose a significant obstacle in the fight …