Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine
thymoma viral oncogene homolog (AKT) plays a major role in the PI3K/AKT signaling …

Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

Context: Increasing incidence and impact of inflammatory diseases have encouraged the
search of new pharmacological strategies to face them. Licorice has been used to treat …

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is highly aggressive
and hypoxic compared with other subtypes. The role of hypoxia inducible factor 1α (HIF-1α) …

The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Ethnopharmacological relevance Licorice is a medicinal herb with a 2000-year history of
applications in traditional Chinese medicine. Isoliquiritigenin (ISL) is a bioactive chalcone …

Licorice is one of the oldest and most frequently used herbs in traditional Chinese medicine.
It contains more than 20 triterpenoids and 300 flavonoids. In recent years, a lot of studies …

Ethnopharmacological relevance Licorice has been commonly used in traditional Chinese
medicine for treatment of gastric, liver, and respiratory disease conditions for more than two …

Simple Summary Isoliquiritigenin (ISL), a natural bioactive compound with a chalcone
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …

Significance: Hypoxia is emerging as a crucial regulator of the tumor microenvironment; it
governs the metastatic potential of multiple primary cancers. It is also potentially involved in …