Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases,
particularly neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease …

This article continues the series of Surveys and Summaries on restriction endonucleases
(REases) begun this year in Nucleic Acids Research. Here we discuss 'Type II'REases, the …

INTRODUCTION Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) is a nuclear enzyme
responding to oxidative stress and DNA damage. Excessive activation of PARP-1 causes an …

In the type III CRISPR–Cas immune response of prokaryotes, infection triggers the
production of cyclic oligoadenylates that bind and activate proteins that contain a CARF …

One-third of the 4,225 protein-coding genes of Escherichia coli K-12 remain functionally
unannotated (orphans). Many map to distant clades such as Archaea, suggesting …

The bacterial endosymbiont Wolbachia manipulates arthropod reproduction to facilitate its
maternal spread through host populations. The most common manipulation is cytoplasmic …

DNA interstrand crosslinks (ICLs) are highly toxic because they block the progression of
replisomes. The Fanconi Anemia (FA) proteins, encoded by genes that are mutated in FA …

Cytotoxicity of cisplatin and mitomycin C (MMC) is ascribed largely to their ability to generate
interstrand crosslinks (ICLs) in DNA, which block the progression of replication forks. The …

Proteins belonging to PD-(D/E) XK phosphodiesterases constitute a functionally diverse
superfamily with representatives involved in replication, restriction, DNA repair and tRNA …

Understanding how cells dynamically adapt to their environment is a primary focus of
biology research. Temporal information about cellular behavior is often limited by both small …