Natural alkaloids as multi-target compounds towards factors implicated in Alzheimer's disease
R Vrabec, G Blunden, L Cahlíková - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia in elderly people;
currently, there is no efficient treatment. Considering the increase in life expectancy …
currently, there is no efficient treatment. Considering the increase in life expectancy …
Role of Astrocytes in Alzheimer's Disease Pathogenesis and the Impact of Exercise-Induced Remodeling
J Shao, Q Deng, S Feng, C Wu, X Liu, L Yang - … and Biophysical Research …, 2024 - Elsevier
Alzheimer's disease (AD) is a prevalent and debilitating brain disorder that worsens
progressively with age, characterized by cognitive decline and memory impairment. The …
progressively with age, characterized by cognitive decline and memory impairment. The …
[HTML][HTML] Xanthohumol Protects Against Neuronal Excitotoxicity and Mitochondrial Dysfunction in APP/PS1 Mice: An Omics-Based Study
FF Hu, SY Pan, JY Chu, JJ Liu, TT Duan, Y Luo… - Nutrients, 2024 - mdpi.com
Background: Neuronal excitotoxicity and metabolic decline, which begin in the early stages
of Alzheimer's disease (AD), pose challenges for effective amelioration. Our previous work …
of Alzheimer's disease (AD), pose challenges for effective amelioration. Our previous work …
Intranasal Carrier-Free Nanomodulator Addresses Both Symptomatology and Etiology of Alzheimer's Disease by Restoring Neuron Plasticity and Reprogramming …
W Yang, Y Shi, Y Zhang, Y Yang, Y Du, Z Yang… - ACS …, 2024 - ACS Publications
The unsatisfactory treatment outcome of Alzheimer's disease (AD) can be attributed to two
primary factors, the intricate pathogenic mechanisms leading to restricted treatment …
primary factors, the intricate pathogenic mechanisms leading to restricted treatment …
Early rise of glutamate-glutamine levels in mild cognitive impairment: Evidence for emerging excitotoxicity
L Velu, L Pellerin, A Julian, M Paccalin, C Giraud… - Journal of …, 2024 - Elsevier
Background Use proton magnetic resonance spectroscopy (1H-MRS) non invasive
technique to assess the modifications of glutamate-glutamine (Glx) and gammaaminobutyric …
technique to assess the modifications of glutamate-glutamine (Glx) and gammaaminobutyric …
[HTML][HTML] Preclinical Pharmacology of the Low-Impact Ampakine CX717
Ampakines are a class of orally available positive allosteric modulators of the AMPA-
glutamate receptor (AMPAR) and have therapeutic implications for neurological …
glutamate receptor (AMPAR) and have therapeutic implications for neurological …
Hippocampal mGluR5 levels are comparable in Alzheimer′ s and control brains, and divergently influenced by amyloid and tau in control brain
J Wang, S Savodalli, Y Kong, C Mashio, U Konietzko… - bioRxiv, 2024 - biorxiv.org
Background: Metabotropic glutamate receptor 5 (mGluR5) modulates excitatory
glutamatergic synaptic transmission and plays an important role in learning and memory …
glutamatergic synaptic transmission and plays an important role in learning and memory …
Crystal Structure Analysis and Characterization of NADP-Dependent Glutamate Dehydrogenase with Alcohols Activity from Geotrichum candidum
J Zhu, H Hou, K Li, X Xu, C Jiang, D Shao, J Shi, D Yin - Crystals, 2023 - mdpi.com
To better understand its mechanism of activity towards higher alcohols, we overexpressed
and purified new Geotrichum candidum GDH (Gc GDH). The purified Gc GDH (50.27 kDa) …
and purified new Geotrichum candidum GDH (Gc GDH). The purified Gc GDH (50.27 kDa) …
[PDF][PDF] Systems Medicine for the Molecular Characterization of Alzheimer's Disease and the Drug Repurposing Strategy
Alzheimer's disease (AD) is a complex multifactorial brain disorder characterised by
dementia, neurodegeneration, plaques and neurofibrillary tangles in elderly people. The …
dementia, neurodegeneration, plaques and neurofibrillary tangles in elderly people. The …
[HTML][HTML] How Can Drugs Affect Glutamate?
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