The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung
Alveolar type II (ATII) cells are a key structure of the distal lung epithelium, where they exert
their innate immune response and serve as progenitors of alveolar type I (ATI) cells …
their innate immune response and serve as progenitors of alveolar type I (ATI) cells …
[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …
human physiopathology with striking discrepancies in estimating drug efficacy and side …
3D bioprinted organ‐on‐chips
S Rahmani Dabbagh, M Rezapour Sarabi… - …, 2023 - Wiley Online Library
Abstract Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more
realistically compared to many animal models and conventional two‐dimensional cell …
realistically compared to many animal models and conventional two‐dimensional cell …
Emerging delivery approaches for targeted pulmonary fibrosis treatment
Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …
Microfluidic organ-on-a-chip system for disease modeling and drug development
Z Li, J Hui, P Yang, H Mao - Biosensors, 2022 - mdpi.com
An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering
to replicate the critical physiological environment and functions of the human organs …
to replicate the critical physiological environment and functions of the human organs …
Novel drug delivery systems and disease models for pulmonary fibrosis
R Li, Y Jia, X Kong, Y Nie, Y Deng, Y Liu - Journal of Controlled Release, 2022 - Elsevier
Pulmonary fibrosis (PF) is a serious and progressive lung disease which is possibly life-
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …
Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization
As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …
Tailoring biomaterials for biomimetic organs-on-chips
Organs-on-chips are microengineered microfluidic living cell culture devices with
continuously perfused chambers penetrating to cells. By mimicking the biological features of …
continuously perfused chambers penetrating to cells. By mimicking the biological features of …
A robust method for perfusable microvascular network formation in vitro
Micropost‐based microfluidic devices are widely used for microvascular network (MVN)
formation in diverse research fields. However, consistently generating perfusable MVNs of …
formation in diverse research fields. However, consistently generating perfusable MVNs of …
Recent advances of biosensor-integrated organ-on-a-chip technologies for diagnostics and therapeutics
Conventional preclinical evaluation implemented in 2D monolayer cultures falls short with
multiorgan interactions, while animal systems lack the specificity of the human species …
multiorgan interactions, while animal systems lack the specificity of the human species …